Treatment of dysplastic Barrett’s Oesophagus in lower volume centres after structured training

Whole genome methylation analysis of non-dysplastic Barretts oesophagus that progresses to invasive cancer

Objective: To investigate differences in methylation between patients with nondysplastic Barretts’ oesophagus who progress to invasive adenocarcinoma and those that do not. Design: A whole genome methylation interrogation using the Illumina HumanMethylation 450 array of patients with non-dysplastic Barrett’s Oesophagus who either develop adenocarcinoma or remain static, with validation of findi...

Endoscopic Detection and Eradication of Dysplastic Barrett's Oesophagus

The lower end of the oesophagus.

The lower end of the oesophagus is a region where the pathology, the physiology, and even the anatomy are not quite clear. This paper attempts to dispel some of the confusion. WHERE IS THE OESOPHAGO-GASTRIC JUNCTION ? The oesophagus or gullet is the tube which conducts food from the throat to the stomach, and the stomach is the pouch in which food collects and undergoes the initial stages of di...

Structured treatment interruptions: after SMART.

The recent termination of several major studies of structured treatment interruption (STI)--the term for taking a planned break from anti-HIV medications--has drawn heightened attention to this treatment strategy. Always a controversial and intriguing approach, STI has been the focus of large-scale trials only in the last several years. Since January, three such studies have been halted early a...

Accumulation of p53 protein in normal, dysplastic, and neoplastic Barrett's oesophagus.

Accumulation of p53 protein was determined by immunohistochemistry in archival material of biopsy specimens from 102 patients with Barrett's oesophagus with different grades of dysplasia, in 24 oesophageal adenocarcinomas associated with Barrett's oesophagus, and in 23 cases of metaplastic epithelium adjacent to these carcinomas. Immunostaining for the p53 protein was found in 23/102 (23 per ce...